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The identification and characteristics of IL-22-producing T cells in acute graft-versus-host disease following allogeneic bone marrow transplantation.
- Source :
-
Immunobiology . Dec2013, Vol. 218 Issue 12, p1505-1513. 9p. - Publication Year :
- 2013
-
Abstract
- Abstract: Graft-versus-host disease (GVHD) remains the major obstacle for allogeneic bone marrow transplantation, in which many proinflammatory cytokines secreted by alloreactive donor T cells are involved. Role of IL-22 as a member of IL-10 family in GVHD is still disputed and the properties of IL-22-producing cells are unclear. We demonstrated here that CD4+ T cells but not CD8+ T cells involved in GVHD were the main cellular source of donor-derived IL-22. Th1 and Th17 cells were detected not only express classical cytokine IFN-γ or IL-17, but also contributed to IL-22 secretion in GVHD. Th22 cells characterized by the independent secretion of IL-22 were identified and occupied almost half percentage of IL-22-producing CD4+ T cells. The frequency of IL-22-producing CD4+ T cells showed dynamic changes with the development of GVHD. Finally, we observed that IL-22-producing CD4+ T cells in GVHD mouse carried CD62L−CD44high/low surface markers. In conclusion, we illuminate the characteristics of donor-derived IL-22-producing CD4+ T cells, which may have potent implication for further study of pathogenesis of GVHD. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 01712985
- Volume :
- 218
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Immunobiology
- Publication Type :
- Academic Journal
- Accession number :
- 91265577
- Full Text :
- https://doi.org/10.1016/j.imbio.2013.05.005