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CD36-mediated endocytic uptake of advanced glycation end products (AGE) in mouse 3T3-L1 and human subcutaneous adipocytes
- Source :
-
FEBS Letters . Feb2003, Vol. 537 Issue 1-3, p85. 6p. - Publication Year :
- 2003
-
Abstract
- Interaction of advanced glycation end products (AGE) with AGE receptors induces several cellular phenomena potentially relating to diabetic complications. We here show that AGE-modified bovine serum albumin (BSA) is endocytosed by adipocytes via CD36. Upon differentiation, 3T3-L1 and human subcutaneous adipose cells showed marked increases in endocytic uptake and subsequent degradation of [125I]AGE-BSA, which were inhibited effectively by the anti-CD36 antibody. Ligand specificity of CD36 for modified BSAs was compared with that of LOX-1 and scavenger receptor class A. Effect of fucoidan on [125I]AGE-BSA binding showed a sharp contrast to that on [125I]-oxidized low density lipoprotein. These results implicate that CD36-mediated interaction of AGE-modified proteins with adipocytes might play a pathological role in obesity or insulin-resistance. [Copyright &y& Elsevier]
- Subjects :
- *SERUM albumin
*DIABETES complications
Subjects
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 537
- Issue :
- 1-3
- Database :
- Academic Search Index
- Journal :
- FEBS Letters
- Publication Type :
- Academic Journal
- Accession number :
- 9145290
- Full Text :
- https://doi.org/10.1016/S0014-5793(03)00096-6