Toward the natural didemnaketal A: total synthesis of the isomer of didemnaketal A.

Authors :: Peng, Lei
Zhang, Fu-Min
Yang, Bing-Miao
Zhang, Xiao-Bo
Liu, Wen-Xing
Zhang, Shu-Yu
Tu, Yong-Qiang
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Nov2013, Vol. 54 Issue 48, p6514-6516. 3p.
Publication Year :: 2013
Abstract: Abstract: The total synthesis of isomer of didemnaketal A was achieved in 26 steps. The position of esters is switched at C7 and C8 with respect to their proposed position in natural didemnaketal A, which shows potent anti-HIV activity but so far has not been synthesized in the laboratory. Structural analysis of synthetic isomer of didemnaketal A indicates that the esters at C7 and C8 are correctly assigned, suggesting that the problems for the structural reassignment of natural didemnaketal A lie elsewhere. [Copyright &y& Elsevier]

Subjects :: *ISOMER synthesis
*ANTIVIRAL agents
*DRUG synergism
*ESTERS
*MOLECULAR structure
*ORGANIC chemistry

Language :: English
ISSN :: 00404039
Volume :: 54
Issue :: 48
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 91600061
Full Text :: https://doi.org/10.1016/j.tetlet.2013.09.078

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