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Downregulation of Nrf2/HO-1 pathway and activation of JNK/c-Jun pathway are involved in homocysteic acid-induced cytotoxicity in HT-22 cells.
- Source :
-
Toxicology Letters . Oct2013, Vol. 223 Issue 1, p1-8. 8p. - Publication Year :
- 2013
-
Abstract
- Highlights: [•] Homocysteic acid (HCA) induces neurotoxicity in dose- and time-dependent manners. [•] HCA decreases the ratio of Bcl-2/Bax, but in a Caspase-3-independent way. [•] HCA induces oxidative stress and decreased the levels of the Nrf2 and HO-1. [•] The toxicity of HCA is attenuated by SP600125. [•] HCA increases the levels of p-c-Jun and p-JNK. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 03784274
- Volume :
- 223
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Toxicology Letters
- Publication Type :
- Academic Journal
- Accession number :
- 91600831
- Full Text :
- https://doi.org/10.1016/j.toxlet.2013.08.011