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Rescuing Auxotrophic Microorganisms with Nonenzymatic Chemistry.

Authors :
Lee, Yunmi
Umeano, Afoma
Balskus, Emily P.
Source :
Angewandte Chemie International Edition. Nov2013, Vol. 52 Issue 45, p11800-11803. 4p.
Publication Year :
2013

Abstract

Organic chemistry to the rescue: Two unrelated nonenzymatic chemical reactions can support the growth of auxotrophic E. coli strains by generating essential nutrients in situ. These biocompatible reactions, which take place in the presence of the organisms and are designed to interface with cellular metabolic processes, provide a means of linking the growth of an organism to the success of a nonbiological chemical transformation. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14337851
Volume :
52
Issue :
45
Database :
Academic Search Index
Journal :
Angewandte Chemie International Edition
Publication Type :
Academic Journal
Accession number :
91673489
Full Text :
https://doi.org/10.1002/anie.201307033