A small compound targeting the interaction between nonstructural proteins 2B and 3 inhibits dengue virus replication.

Authors :: Pambudi, Sabar
Kawashita, Norihito
Phanthanawiboon, Supranee
Omokoko, Magot Diata
Masrinoul, Promsin
Yamashita, Akifumi
Limkittikul, Kriengsak
Yasunaga, Teruo
Takagi, Tatsuya
Ikuta, Kazuyoshi
Kurosu, Takeshi
Source :: Biochemical & Biophysical Research Communications. Oct2013, Vol. 440 Issue 3, p393-398. 6p.
Publication Year :: 2013
Abstract: Highlights: [•] A small compound SK-12 inhibits protease activity of dengue virus. [•] SK-12 interferes with the interaction between nonstructural proteins 2B and 3. [•] SK-12 is a noncompetitive inhibitor. [•] The Q27 in dengue virus nonstructural protein 3 is a key amino acid for inhibition. [ABSTRACT FROM AUTHOR]

Subjects :: *DENGUE viruses
*VIRAL replication
*PROTEASE inhibitors
*AMINO acids
*BIOMOLECULES

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