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A small compound targeting the interaction between nonstructural proteins 2B and 3 inhibits dengue virus replication.
- Source :
-
Biochemical & Biophysical Research Communications . Oct2013, Vol. 440 Issue 3, p393-398. 6p. - Publication Year :
- 2013
-
Abstract
- Highlights: [•] A small compound SK-12 inhibits protease activity of dengue virus. [•] SK-12 interferes with the interaction between nonstructural proteins 2B and 3. [•] SK-12 is a noncompetitive inhibitor. [•] The Q27 in dengue virus nonstructural protein 3 is a key amino acid for inhibition. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DENGUE viruses
*VIRAL replication
*PROTEASE inhibitors
*AMINO acids
*BIOMOLECULES
Subjects
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 440
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 91693978
- Full Text :
- https://doi.org/10.1016/j.bbrc.2013.09.078