Neuronal nitric oxide synthase and NADPH oxidase interact to affect cognitive, affective, and social behaviors in mice.

Highlights: [•] Concurrent deletion of nNOS and p47phox (NOX) alters behavior in mice. [•] nNOS and NOX deletions synergize to impair cognitive function. [•] Deletion of nNOS or NOX alone impairs social behavior. [•] Deletion of nNOS and NOX together enhances social preference. [•] Current findings may provide insight into schizophrenia and autism. [ABSTRACT FROM AUTHOR]