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Rare-earth-incorporated polymeric vector for enhanced gene delivery.
- Source :
-
Biomaterials . Jan2014, Vol. 35 Issue 1, p479-488. 10p. - Publication Year :
- 2014
-
Abstract
- Abstract: Cationic polymer PEI-CyD is doped with Nd by plasma technology to produce the gene vector: Nd@PEI-CyD. Luciferase expression and EGFP transfection experiments performed in vitro reveal that Nd@PEI-CyD has significantly higher transfection efficiency than lipofectamine 2000 and PEI-CyD and the mechanism is studied and proposed. The rare-earth element, Nd, stimulates the energy metabolism of cells, enhances cell uptake of complexes/pDNA, and regulates the cellular pathways. These special features suggest a new strategy involving metal-incorporated non-viral gene vectors. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 01429612
- Volume :
- 35
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Biomaterials
- Publication Type :
- Academic Journal
- Accession number :
- 91740255
- Full Text :
- https://doi.org/10.1016/j.biomaterials.2013.09.069