Back to Search
Start Over
Terpenoids and their anti-HIV-1 activities from Excoecaria acerifolia.
- Source :
-
Fitoterapia . Dec2013, Vol. 91, p224-230. 7p. - Publication Year :
- 2013
-
Abstract
- Abstract: Five new diterpenoids named excocarinols A–E (1–5) including three pimaranes, one cleistanthane, and one nor-beyerane, together with nine known compounds, were isolated from the EtOAc extract of the Chinese ethnodrug Gua-jing-ban (Excoecaria acerifolia Didr.). Their structures were elucidated by the analysis of spectroscopic data including 1D, 2D NMR and HR-MS. The anti-HIV-1 bioassay on the diterpenoids showed that excocarinol A (1) exhibited moderate anti-HIV-1 activity with EC50 5.58?M and SI (Selection Index) over 112.71. [Copyright &y& Elsevier]
- Subjects :
- *ALTERNATIVE medicine
*ANTIVIRAL agents
*BIOLOGICAL assay
*DOSE-effect relationship in pharmacology
*HIV
*MASS spectrometry
*MEDICINAL plants
*MICROBIAL sensitivity tests
*NUCLEAR magnetic resonance spectroscopy
*PHYTOCHEMICALS
*PLANT extracts
*DESCRIPTIVE statistics
*IN vitro studies
*PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 0367326X
- Volume :
- 91
- Database :
- Academic Search Index
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 91743264
- Full Text :
- https://doi.org/10.1016/j.fitote.2013.09.007