Gremlin-1 Is an Inhibitor of Macrophage Migration Inhibitory Factor and Attenuates Atherosclerotic Plaque Growth in ApoE-/-Mice.

Authors :: Müller, Iris
Schönberger, Tanja
Schneider, Martina
Borst, Oliver
Ziegler, Melanie
Seizer, Peter
Leder, Christoph
Müller, Karin
Lang, Michael
Appenzeller, Florian
Lunov, Oleg
Büchele, Berthold
Fahrleitner, Manuela
Olbrich, Marcus
Langer, Harald
Geisler, Tobias
Lang, Florian
Chatterjee, Madhumita
de Boer, Jan Freark
Tietge, Uwe J. F.
Source :: Journal of Biological Chemistry. 11/1/2013, Vol. 288 Issue 44, p31634-31645. 12p.
Publication Year :: 2013
Abstract: Results: Gremlin-1 binds with high affinity to macrophage migration inhibitory factor and attenuates the progression of atherosclerosis. Conclusion: We describe a novel mechanism that regulates foam cell formation and plaque growth. Significance: The findings disclose a new mechanism for the regulation of plaque growth and may open novel therapeutic strategies to control the progression of atherosclerosis. [ABSTRACT FROM AUTHOR]

Subjects :: *MACROPHAGE migration inhibitory factor
*ATHEROSCLEROSIS
*DISEASE progression
*LABORATORY mice
*ENDOTHELIAL cells

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