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A novel TK-NOG based humanized mouse model for the study of HBV and HCV infections.

Authors :
Kosaka, Keiichi
Hiraga, Nobuhiko
Imamura, Michio
Yoshimi, Satoshi
Murakami, Eisuke
Nakahara, Takashi
Honda, Yoji
Ono, Atsushi
Kawaoka, Tomokazu
Tsuge, Masataka
Abe, Hiromi
Hayes, C. Nelson
Miki, Daiki
Aikata, Hiroshi
Ochi, Hidenori
Ishida, Yuji
Tateno, Chise
Yoshizato, Katsutoshi
Sasaki, Tamito
Chayama, Kazuaki
Source :
Biochemical & Biophysical Research Communications. Nov2013, Vol. 441 Issue 1, p230-235. 6p.
Publication Year :
2013

Abstract

Highlights: [•] TK-NOG mice with humanized livers are available for hepatitis viruses infection. [•] The infectiveness with hepatitis viruses is as well or better than uPA/SCID mice. [•] Humanized TK-NOG mouse is a useful animal model for the study of hepatitis viruses. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0006291X
Volume :
441
Issue :
1
Database :
Academic Search Index
Journal :
Biochemical & Biophysical Research Communications
Publication Type :
Academic Journal
Accession number :
91816498
Full Text :
https://doi.org/10.1016/j.bbrc.2013.10.040