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Inhibitor selectivity between aldo–keto reductase superfamily members AKR1B10 and AKR1B1: Role of Trp112 (Trp111).
- Source :
-
FEBS Letters . Nov2013, Vol. 587 Issue 22, p3681-3686. 6p. - Publication Year :
- 2013
-
Abstract
- Highlights: [•] Crystal structures of AKR1B10 holoenzyme. [•] Trp112 side-chain flipping in AKR1B10 explains non-selectivity of AKR1B1 inhibitors. [•] Native Trp112 side-chain orientation is critical for selective AKR1B10 inhibitors. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 587
- Issue :
- 22
- Database :
- Academic Search Index
- Journal :
- FEBS Letters
- Publication Type :
- Academic Journal
- Accession number :
- 91848661
- Full Text :
- https://doi.org/10.1016/j.febslet.2013.09.031