Functional recovery after transplantation of induced pluripotent stem cells in a rat hemorrhagic stroke model.

Highlights: [•] We assessed the therapeutic effect of iPSCs in experimental ICH rat. [•] Therapeutic effects of iPSCs in rat ICH model were observed. [•] The grafted iPSCs exhibited neural cell-specific biomarkers in the brain of ICH rats. [•] The levels of BDNF and VEGF were enhanced in the surrounding region of hematoma. [•] Functional improvement is partially due to neuronal replacement and neurophic factors. [ABSTRACT FROM AUTHOR]