Back to Search
Start Over
Arctigenin promotes cholesterol efflux from THP-1 macrophages through PPAR-γ/LXR-α signaling pathway.
- Source :
-
Biochemical & Biophysical Research Communications . Nov2013, Vol. 441 Issue 2, p321-326. 6p. - Publication Year :
- 2013
-
Abstract
- Highlights: [•] Arctigenin enhanced cholesterol efflux in oxLDL-loaded THP-1 macrophages. [•] The expression of ABCA1, ABCG1 and apoE was upregulated in arctigenin-treated cells. [•] Arctigenin promoted the expression of PPAR-γ and LXR-α. [•] Inhibition of PPAR-γ or LXR-α reversed arctigenin-mediated biological effects. [•] Arctigenin promotes cholesterol efflux via activation of PPAR-γ/LXR-α/ABCA1 pathway. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 441
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 91921256
- Full Text :
- https://doi.org/10.1016/j.bbrc.2013.10.050