Sarsasapogenin induces apoptosis via the reactive oxygen species-mediated mitochondrial pathway and ER stress pathway in HeLa cells.

Highlights: [•] SAR induced apoptosis via the caspase-dependent mitochondrial apoptosis pathway. [•] SAR activated UPR signaling pathways. [•] SAR provoked the generation of ROS. [•] The generation of ROS was necessary for ER stress mitochondrial apoptotic pathways. [•] Sarsasapogenin (SAR) retarded the cell cycle at S and G2 phase. [Copyright &y& Elsevier]