The cell biology of synaptic specificity during development.

Highlights: [•] Correct circuit connectivity requires both specific partner recognition and proper synaptic assembly. [•] Synaptic specificity is directed through cell-surface, secreted, and intracellular factors. [•] Similar mechanisms direct both laminar and subcellular specificity. [•] Cytoskeletal dynamics underpin synapse formation downstream of specificity factors. [Copyright &y& Elsevier]