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Effect of zeranol on expression of apoptotic and cell cycle proteins in murine placentae.

Authors :
Wang, Yanfei
Li, Lu
Wang, C.C.
Leung, Lai K.
Source :
Toxicology. Dec2013, Vol. 314 Issue 1, p148-154. 7p.
Publication Year :
2013

Abstract

Highlights: [•] Zeranol administered at 1–100mg/kg/day demonstrated an increasing trend of fetal resorption and early delivery in mice. [•] Placental expression of Cdk2 and 4, Cyclin D1 and Bcl-xL were reduced mostly in mice treated with ≥10mg zeranol/kg/day. [•] Increased pErk-1 and 2 were also observed in the placentae of zeranol-treated mice. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
0300483X
Volume :
314
Issue :
1
Database :
Academic Search Index
Journal :
Toxicology
Publication Type :
Academic Journal
Accession number :
91953946
Full Text :
https://doi.org/10.1016/j.tox.2013.09.011