Development of a method to isolate circulating tumor cells using mesenchymal-based capture.

Highlights: [•] Epithelial plasticity is likely an important mechanism for cancer metastasis. [•] Circulating tumor cells with mesenchymal features may be missed by standard methods. [•] We describe a novel mesenchymal-based circulating tumor cell capture method. [•] This approach is evaluated in healthy volunteers and men with prostate cancer. [Copyright &y& Elsevier]