Cerebral 5-HT2A receptor binding, but not mGluR2, is increased in tryptophan hydroxylase 2 decrease-of-function mice.

Highlights: [•] Significant increase in binding of two radio-ligands to the 5-HT2A receptor in transgene mice earlier shown to have reduced 5-HT levels. [•] The change in 5-HT2A receptor binding is anatomical specific. [•] No change in mGluR2/3 receptor binding in mice with higher levels of 5-HT2A receptor binding. [ABSTRACT FROM AUTHOR]