Progressive symmetrical erythrokeratoderma: report of two Chinese families and evaluation for mutations in the loricrin, connexin 30.3 and connexin 31 genes.

The article discusses a study on the genetic analysis of two Chinese families with inherited autosomal progressive symmetrical erythrokeratoderma (PSEK). The researchers assessed the oricrin, connexin 30.3 and connexin 31 genes of the two families and revealed no mutations of these genes. It suggests that more than one genetic locus is responsible for the development of PSEK.