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Phosphine-Catalyzed Asymmetric [4+2] Annulation of Vinyl Ketones with Oxindole-Derived α,β-Unsaturated Imines: Enantioselective Syntheses of 2′,3′-Dihydro-1′ H-spiro[indoline-3,4′-pyridin]-2-ones.
- Source :
-
Advanced Synthesis & Catalysis . Nov2013, Vol. 355 Issue 17, p3351-3357. 7p. - Publication Year :
- 2013
-
Abstract
- A novel asymmetric [4+2] annulation of vinyl ketones with oxindole-derived α,β-unsaturated imines has been developed in the presence of a multifunctional thiourea-phosphine catalyst derived from a natural amino acid, providing the first phosphine-catalyzed enantioselective synthesis of 2′,3′-dihydro-1′ H-spiro[indoline-3,4′-pyridin]-2-ones in good yields with excellent stereoselectivities under mild conditions. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16154150
- Volume :
- 355
- Issue :
- 17
- Database :
- Academic Search Index
- Journal :
- Advanced Synthesis & Catalysis
- Publication Type :
- Academic Journal
- Accession number :
- 92049268
- Full Text :
- https://doi.org/10.1002/adsc.201300828