A methylated oligonucleotide inhibits IGF2 expression and enhances survival in a model of hepatocellular carcinoma.

Authors :: Xiaoming Yao
Ji-Fan Hu
Daniels, Mark
Shiran, Hadas
Xiangjun Zhou
Huifan Yan
Hongju Lu
Zhilan Zeng
Qingxue Wang
Tao Li
Hoffman, Andrew R.
Source :: Journal of Clinical Investigation. 1/15/2003, Vol. 111 Issue 2, p265. 9p.
Publication Year :: 2003
Abstract: Presents a study that designed a methylated oligonucleotide (MON1) complementary to a region encompassing insulin-like growth factor (IGF)2 promoter P4 in an attempt to induce DNA methylation at the locus and diminish IGF2 mRNA levels. Background on IGF2; Methodology; Results of the study.

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