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Extensive diversification of MHC in Chinese giant salamanders Andrias davidianus (Anda-MHC) reveals novel splice variants.
- Source :
-
Developmental & Comparative Immunology . Feb2014, Vol. 42 Issue 2, p311-322. 12p. - Publication Year :
- 2014
-
Abstract
- Highlights: [•] First characterization of MHC alleles in the Chinese giant salamander Andrias davidianus. [•] Anda-MHC genes exhibit high allelic diversity maintained by positive selection acting on the PBR. [•] Two isoforms (full-length and splice transcripts) of Anda-MHC coexist in various tissues. [•] Anda-MHC variants display similar subcellular localization with the full-length transcripts. [•] Anda-MHC gene expression was increased during viral infection. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0145305X
- Volume :
- 42
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Developmental & Comparative Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 92502014
- Full Text :
- https://doi.org/10.1016/j.dci.2013.10.001