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Peripheral neuropathy in cystic fibrosis: A prevalence study.
- Source :
-
Journal of Cystic Fibrosis . Dec2013, Vol. 12 Issue 6, p754-760. 7p. - Publication Year :
- 2013
-
Abstract
- Abstract: Background: Information on peripheral neuropathy in children with cystic fibrosis is scanty. The etiology can be multifactorial (micronutrient deficiency, chronic hypoxia, impaired glucose tolerance, immunological, vasculopathic, critical illness). Methods: Forty five cystic fibrosis children aged 1–18years on vitamin E supplementation for at least 6months underwent detailed neurological examination, serum vitamin E, vitamin B12, folate, copper levels and detailed nerve conduction studies. Results: The mean age of the study population was 8.35years (±4.9years) with 62.2% being males. Overall 22 out of 45 (48.88%,CI: 33.7–64.2) had electrophysiological evidence of peripheral neuropathy which was predominantly axonal (86.4%), sensory (50%), and polyneuropathy (95.45%). There was no significant association between status of serum micronutrients and electrophysiological evidence of peripheral neuropathy. Conclusion: Patients with cystic fibrosis have electrophysiological evidence of peripheral neuropathy (predominantly axonal, sensory and polyneuropathy). There is significant association of higher chronological age with occurrence of peripheral neuropathy. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 15691993
- Volume :
- 12
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journal of Cystic Fibrosis
- Publication Type :
- Academic Journal
- Accession number :
- 92502264
- Full Text :
- https://doi.org/10.1016/j.jcf.2013.01.005