Sulforaphane mitigates genotoxicity induced by radiation and anticancer drugs in human lymphocytes.

Authors :: Katoch, Omika
Kumar, Arun
Adhikari, Jawahar S.
Dwarakanath, Bilikere S.
Agrawala, Paban K.
Source :: Mutation Research - Genetic Toxicology & Environmental Mutagenesis. Dec2013, Vol. 758 Issue 1/2, p29-34. 6p.
Publication Year :: 2013
Abstract: Highlights: [•] CBMN assay of radiation accident victims in India was performed. [•] Sulforaphane was evaluated for its anti-mutagenic potential in vitro. [•] Sulforaphane also ameliorated bleomycin and doxorubicin induced genotoxicity. [•] Sulforaphane enhanced CD 34+Lin− cell survival. [•] Sulforaphane restored the normal HDAC activity level in irradiated lymphocytes. [Copyright &y& Elsevier]

Subjects :: *SULFORAPHANE
*GENETIC toxicology
*RADIATION exposure
*ANTINEOPLASTIC agents
*LYMPHOCYTES
*IN vitro studies

Language :: English
ISSN :: 13835718
Volume :: 758
Issue :: 1/2
Database :: Academic Search Index
Journal :: Mutation Research - Genetic Toxicology & Environmental Mutagenesis
Publication Type :: Academic Journal
Accession number :: 92503648
Full Text :: https://doi.org/10.1016/j.mrgentox.2013.08.009

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