Twinkle mutation in an Italian family with external progressive ophthalmoplegia and parkinsonism: A case report and an update on the state of art.

Highlights: [•] We here describe a family with two sisters and one son affected by a PEO1 mutation. [•] The sisters had a clinical parkinsonism confirmed by FP-CIT SCAN. [•] The characteristics of parkinsonisms are fully described in the paper. [•] The paper provides a short review of the phenotypes of the parkinsonisms associated to PEO1 mutation described in the literature. [Copyright &y& Elsevier]