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MEK1 promotes YAP and their interaction is critical for tumorigenesis in liver cancer.
- Source :
-
FEBS Letters . Dec2013, Vol. 587 Issue 24, p3921-3927. 7p. - Publication Year :
- 2013
-
Abstract
- Highlights: [•] MEK1 controls both YAP expression and activity independent of ERK and Hippo pathway. [•] MEK1 regulates YAP independent of transcription. [•] MEK1 interacts and correlates with YAP expression in liver cancers. [•] MEK1 controls BTRC expression, which may serve as a novel YAP protector. [•] The interaction between YAP and MEK1 promotes tumorigenesis in liver cancer. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 587
- Issue :
- 24
- Database :
- Academic Search Index
- Journal :
- FEBS Letters
- Publication Type :
- Academic Journal
- Accession number :
- 92643148
- Full Text :
- https://doi.org/10.1016/j.febslet.2013.10.042