Hormone-regulated transcriptomes: Lessons learned from estrogen signaling pathways in breast cancer cells.

Highlights: [•] Global nuclear run-on sequencing (GRO-seq) can be used to map transcriptomes. [•] GRO-seq tracks the position and orientation of actively transcribing RNA polymerases. [•] GRO-seq has been used to explore estrogen responses in breast cancer cells. [•] GRO-seq has identified novel, unannotated, estrogen-regulated non-coding RNAs. [•] These studies have elucidated the molecular logic of mitogenic responses. [ABSTRACT FROM AUTHOR]