The effect of childhood obstructive sleep apnea on ambulatory blood pressure is modulated by the distribution of respiratory events during rapid eye movement and nonrapid eye movement sleep.

Objective: We aimed to investigate if different childhood obstructive sleep apnea (OSA) subtypes, namely rapid eye movement (REM)-related, nonrapid eye movement (NREM)-related and stage-independent OSA would exert different effects on ambulatory blood pressure (ABP). Methods: Data from our previous school-based cross-sectional study were reanalyzed. Subjects who had an obstructive apnea–hypopnea index (OAHI) between 1 and 10 events per hour and a total REM sleep duration of >30min were included in our analysis. REM-related and NREM-related OSA were defined as a ratio of OAHI in REM sleep (OAHIREM) to OAHI in NREM sleep (OAHINREM) of >2 and <0.5, respectively. The others were classified as stage-independent OSA. Results: A total of 162 subjects were included in the analysis. In the mild OSA (OAHI, 1–5events/h) subgroup, no significant differences in any ABP parameters were found between OSA subtypes. On the other hand, in subjects with moderate OSA (OAHI, 5–10events/h), the REM-related OSA subtype had a significantly lower daytime systolic blood pressure (SBP) z score (−0.13±0.90 cf 1.15±0.67; P =.012) and nighttime SBP z score (0.29±1.06 cf 1.48±0.88, P =.039) than the stage-independent OSA subtype. Linear regression analyses revealed that OAHINREM but not OAHIREM was significantly associated with both daytime (P =.008) and nighttime SBP (P =.042) after controlling for age, gender, and body size. Conclusion: Children with obstructive events mainly in REM sleep may have less cardiovascular complications than those with stage-independent OSA. [ABSTRACT FROM AUTHOR]