Isoquercetin protects cortical neurons from oxygen–glucose deprivation–reperfusion induced injury via suppression of TLR4–NF-кB signal pathway.

Highlights: [•] Neuroprotective effect of isoquercetin was studied in neuron OGD/R injury model. [•] The mechanism of isoquercetin relies on the anti-inflammation and anti-apoptosis. [•] TLR4 and NF-κB are involved in the anti-inflammatory signaling pathway. [•] ERK, JNK and p38 are involved in the anti-apoptotic signaling pathway. [•] Inhibition of caspase-3 contributes to the improvement from OGD/R injury. [ABSTRACT FROM AUTHOR]