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Differential sensitivity of p44/p42-MAPK- and PI3K/Akt-targeted neuroblastoma subtypes to arsenic trioxide.
- Source :
-
Neurochemistry International . Dec2013, Vol. 63 Issue 8, p809-817. 9p. - Publication Year :
- 2013
-
Abstract
- Highlights: [•] ATO treatment decreases proliferation of neuroblastoma SK-N-BE(2) and SK-N-MC cells. [•] Inhibition of PI3K or MAPK sensitizes NB cells to low doses of ATO. [•] Inhibition of PI3K and MAPK act synergistically with ATO in I-type NB cells. [•] Different subtypes of NB require different treatments. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01970186
- Volume :
- 63
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Neurochemistry International
- Publication Type :
- Academic Journal
- Accession number :
- 92650442
- Full Text :
- https://doi.org/10.1016/j.neuint.2013.10.005