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Effect of human 15-lipoxygenase-1 metabolites on vascular function in mouse mesenteric arteries and hearts.

Authors :
Kriska, Tamas
Cepura, Cody
Siangjong, Lawan
Wan, Tina C.
Auchampach, John A.
Shaish, Aviv
Haratz, Dror
Kumar, Ganesh
Falck, John R.
Gauthier, Kathryn M.
Campbell, William B.
Source :
Prostaglandins & Other Lipid Mediators. Oct2013, Vol. 106, p8-15. 8p.
Publication Year :
2013

Abstract

Highlights: [•] Arachidonic acid metabolites of human 15-LO enzyme are vasoactive. [•] Preproendothelin-1 controlled human 15-LO transgene is highly expressed in heart. [•] Human 15-LO transgene enhances coronary flow following an ischemia. [•] 15-LO metabolites contribute to coronary reactive hyperemia. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10988823
Volume :
106
Database :
Academic Search Index
Journal :
Prostaglandins & Other Lipid Mediators
Publication Type :
Academic Journal
Accession number :
92655720
Full Text :
https://doi.org/10.1016/j.prostaglandins.2013.07.002