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Repair kinetics of acrolein- and (E)-4-hydroxy-2-nonenal-derived DNA adducts in human colon cell extracts.
- Source :
-
Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis . Nov2013, Vol. 751-752, p15-23. 9p. - Publication Year :
- 2013
-
Abstract
- Highlights: [•] The repair kinetics of two common cyclic DNA adducts derived lipid peroxidation, Acr-dG and HNE-dG, in human colon cells was studied. [•] This study is the first to measure DNA repair rates by both DNA repair synthesis and LC–MS/MS methods. [•] Acr-dG, like HNE-dG, is repaired by NER pathway, but it is repaired at a much slower rate compared to HNE-dG. [•] HNE-dG can inhibit the repair of Acr-dG if both are present in the same DNA. [ • ] These results provide an explanation for the higher levels of Acr-dG than HNE-dG observed in vivo. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00275107
- Volume :
- 751-752
- Database :
- Academic Search Index
- Journal :
- Mutation Research: Fundamental & Molecular Mechanisms of Mutagenesis
- Publication Type :
- Academic Journal
- Accession number :
- 92656664
- Full Text :
- https://doi.org/10.1016/j.mrfmmm.2013.09.004