Carvedilol, a third-generation β-blocker prevents oxidative stress-induced neuronal death and activates Nrf2/ARE pathway in HT22 cells.

Highlights: [•] Carvedilol significantly prevented oxidative stress-induced cell death. [•] Carvedilol significantly decreased the production of ROS. [•] Carvedilol activated Nrf2/ARE pathway. [•] Carvedilol increased the protein levels of HO-1 and NQO-1. [ABSTRACT FROM AUTHOR]