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Construction and characterization of functional anti-epiregulin humanized monoclonal antibodies.
- Source :
-
Biochemical & Biophysical Research Communications . Nov2013, Vol. 441 Issue 4, p1011-1017. 7p. - Publication Year :
- 2013
-
Abstract
- Highlights: [•] Epiregulin may be highly relevant for therapeutic applications. [•] We generated humanized anti-epiregulin antibodies by resurfacing the variable region. [•] Our method identified residues that critically affect antigen binding. [•] Our HM1 antibody had high-affinity targeted cytotoxicity against colon cancer cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 441
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 92682641
- Full Text :
- https://doi.org/10.1016/j.bbrc.2013.11.014