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Synthesis, biological evaluation and docking studies of 4-aryloxymethyl coumarins derived from substructures and degradation products of vancomycin.
- Source :
-
European Journal of Medicinal Chemistry . Dec2013, Vol. 70, p750-757. 8p. - Publication Year :
- 2013
-
Abstract
- Abstract: Two series of 4-aryloxymethyl coumarins derived from the reaction of 4-bromomethyl coumarins with ethyl gallate and ethyl ester of N-Benzoyl tyrosine have been synthesized. Gallate ethers 3aā3g and tyrosine derivatives 4eā4j were most effective against Entercoccus faecalis. They were also found to be effective against Aspergillus niger and Candida albicans. Comparative docking studies with novobiocin have indicated better binding ability and higher āCā score values than novobiocin. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 02235234
- Volume :
- 70
- Database :
- Academic Search Index
- Journal :
- European Journal of Medicinal Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 92728698
- Full Text :
- https://doi.org/10.1016/j.ejmech.2013.10.047