One-Pot Synthesis of Multiply Substituted Quinoline and Quinazoline Derivatives via [2+2+2] Cascade Annulation with Diaryliodonium Salts.

An efficient and regioselective method to multisubstituted quinoline and quinazoline derivatives with diaryliodoniurn salts catalyzed by Cu(OTf)2 has been presented. The reaction proceeded via cascade annulation in the mode of [2+2+2] form. This novel strategy enables use of readily available materials and bears great flexibility on the substitution groups. [ABSTRACT FROM AUTHOR]