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Patterns in Space: Coordinating Adhesion and Actomyosin Contractility at E-cadherin Junctions.

Authors :
Wu, Selwin Kaixiang
Yap, Alpha S.
Source :
Cell Communication & Adhesion. Dec2013, Vol. 20 Issue 6, p201-212. 12p. 5 Diagrams.
Publication Year :
2013

Abstract

Cadherin adhesion receptors are fundamental determinants of tissue organization in health and disease. Increasingly, we have come to appreciate that classical cadherins exert their biological actions through active cooperation with the contractile actin cytoskeleton. Rather than being passive resistors of detachment forces, cadherins can regulate the assembly and mechanics of the contractile apparatus itself. Moreover, coordinate spatial patterning of adhesion and contractility is emerging as a determinant of morphogenesis. Here we review recent developments in cadherins and actin cytoskeleton cooperativity, by focusing on E-cadherin adhesive patterning in the epithelia. Next, we discuss the underlying principles of cellular rearrangement during Drosophila germband extension and epithelial cell extrusion, as models of how planar and apical-lateral patterns of contractility organize tissue architecture. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
15419061
Volume :
20
Issue :
6
Database :
Academic Search Index
Journal :
Cell Communication & Adhesion
Publication Type :
Academic Journal
Accession number :
92867349
Full Text :
https://doi.org/10.3109/15419061.2013.856889