A Pharmacogenetic versus a Clinical Algorithm for Warfarin Dosing.

Authors :: Kimmel, Stephen E.
French, Benjamin
Kasner, Scott E.
Johnson, Julie A.
Anderson, Jeffrey L.
Gage, Brian F.
Rosenberg, Yves D.
Eby, Charles S.
Madigan, Rosemary A.
McBane, Robert B.
Abdel-Rahman, Sherif Z.
Stevens, Scott M.
Yale, Steven
Mohler III, Emile R.
Fang, Margaret C.
Shah, Vinay
Horenstein, Richard B.
Limbi, Nita A.
S. Muldowney III, James A.
Gujral, Jaspal
Source :: New England Journal of Medicine. 12/12/2013, Vol. 369 Issue 24, p2283-2293. 11p. 1 Color Photograph, 3 Charts, 2 Graphs.
Publication Year :: 2013
Abstract: The article offers information on research that tested the clinical utility of genotype-guided or pharmacologically based dosing of warfarin in small clinical trials or observational studies. The trial involved 1015 patients who were assigned to the use of either a genotype-guided algorithm or a clinically guided algorithm for warfarin dosing during the first 5 days. No significant difference in the percentage of time in the therapeutical international normalized ratio range was found.