T cell development in mice that lack the zeta chain of the T cell antigen receptor complex.

Evaluates the importance of zeta in the maturation of T cells. Derivation of zeta-deficient mice from embryonic stem; Examination of endogenous and mutant alleles by Northern (RNA) blotting; Assessment of synthesis of other T cell antigen receptor (TCR) components; Assessment of T cell development in the absence of zeta; Reexamination of the thymuses.