Protein tyrosine kinase inhibitory properties of planar polycyclics obtained from the marine...

Describes the isolation and characterization of planar polycyclics from the marine sponge Xestopongia. Four new metabolites and five known compounds; Determination of structures using nuclear magnetic resonance data; Absolute stereochemistry of chiral centers; Synthesis of polycyclic models of natural products; Ability to inhibit the activity of protein tyrosine kinase.