Chirospecific synthesis of (1S,3R)-1-amino-3-(hydroxymethyl)cyclopentane...

Describes a new method for the synthesis of (1S,3R)-1-amino-3-(hydroxymethyl)cyclopentane. Intramolecular cyclization of an ester enolate onto an activated aziridine; Formation of a substituted pentane ring; Use of arylsulfonate as a substituent; Attempts to produce other forms of cyclopentenes and cyclopentanes; Alterations to improve selectivity of cyclization.