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Preparation and characterization of LA/PCL composite fibers containing beta tricalcium phosphate (β-TCP) particles.
- Source :
-
Ceramics International . Apr2014, Vol. 40 Issue 3, p5049-5054. 6p. - Publication Year :
- 2014
-
Abstract
- Abstract: Beta-TCP (β-TCP) particle-containing LA/PCL micro/nanofibers were fabricated via a one-step electrospinning process. The morphology and chemical structure of the composite nanofibers were characterized by FESEM, XRD, and FTIR. Rougher surfaces were observed for the LA/PCL micro/nanofibers containing β-TCP compared to the neat LA/PCL fibers, which could possibly provide extra sites for cell binding. XRD and FTIR confirmed the presence of β-TCP as being firmly deposited on the fibers. After an immersion in distilled water, we observed that the β-TCP-containing composite fibers were more degradable with many damaged and broken fibers compared to the LA/PCL fibers. MTT assay and immersion test showed better cell viability and proliferation, and improved mineralization ability compared to the LA/PCL only mat. Thus, the incorporation of β-TCP and the presence of LA in PCL micro/nanofibers could result to an improved biocompatibility and faster degradation of the composite fibers, which would possibly be useful for tissue scaffold application. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 02728842
- Volume :
- 40
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Ceramics International
- Publication Type :
- Academic Journal
- Accession number :
- 93267810
- Full Text :
- https://doi.org/10.1016/j.ceramint.2013.10.016