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NF-κB control of T cell development.
- Source :
-
Nature Immunology . Jan2014, Vol. 15 Issue 1, p15-25. 11p. - Publication Year :
- 2014
-
Abstract
- The NF-κB signal transduction pathway is best known as a major regulator of innate and adaptive immune responses, yet there is a growing appreciation of its importance in immune cell development, particularly of T lineage cells. In this Review, we discuss how the temporal regulation of NF-κB controls the stepwise differentiation and antigen-dependent selection of conventional and specialized subsets of T cells in response to T cell receptor and costimulatory, cytokine and growth factor signals. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15292908
- Volume :
- 15
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Nature Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 93303570
- Full Text :
- https://doi.org/10.1038/ni.2785