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Oligomeric proanthocyanidins alleviate hexabromocyclododecane-induced cytotoxicity in HepG2 cells through regulation on ROS formation and mitochondrial pathway.

Authors :
An, Jing
Chen, Cen
Wang, Xiu
Zhong, Yufang
Zhang, Xinyu
Yu, Yingxin
Yu, Zhiqiang
Source :
Toxicology in Vitro. Mar2014, Vol. 28 Issue 2, p319-326. 8p.
Publication Year :
2014

Abstract

Highlights: [•] HBCD induced obvious oxidative damage in HepG2 cells. [•] OPCs could effectively protect cells against HBCD-induced cytotoxicity. [•] ROS formation, mitochondrial pathway, and Ca2+ level are involved in OPCs effect regulation. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
08872333
Volume :
28
Issue :
2
Database :
Academic Search Index
Journal :
Toxicology in Vitro
Publication Type :
Academic Journal
Accession number :
93334362
Full Text :
https://doi.org/10.1016/j.tiv.2013.11.009