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Tussilagone suppresses colon cancer cell proliferation by promoting the degradation of β-catenin.
- Source :
-
Biochemical & Biophysical Research Communications . Jan2014, Vol. 443 Issue 1, p132-137. 6p. - Publication Year :
- 2014
-
Abstract
- Highlights: [•] Tussilagone (TSL) was purified from plant as an inhibitor of Wnt/β-catenin pathway. [•] TSL suppressed the β-catenin/T-cell factor transcriptional activity. [•] The proteasomal degradation of β-catenin was induced by TSL. [•] TSL suppressed the Wnt/β-catenin target genes, cyclin D1 and c-myc. [•] TSL inhibit the proliferation of colon cancer cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 443
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 93336546
- Full Text :
- https://doi.org/10.1016/j.bbrc.2013.11.062