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Fluctuating lymphocyte chimerism, tolerance and anti-tumor response in a patient with refractory lymphoma receiving non-myeloablative conditioning and a haploidentical related allogeneic bone marrow transplant.
- Source :
-
Cytokines Cellular & Molecular Therapy . Jun2002, Vol. 7 Issue 2, p43. 5p. - Publication Year :
- 2002
-
Abstract
- A 51-year-old patient with refractory non-Hodgkin lymphoma (NHL) received non-myeloablative conditioning and a two of six (A, B, DR) human leucocyte antigen (HLA) mismatched donor BMT. Post-BMT lymphocytes showed fluctuating T- and natural killer (NK)-cell chimerism, which culminated in mainly donor lymphocytes by Day + 100. Changes in lymphocyte chimerism correlated with antidonor and anti-host responses in mixed lymphocyte reaction (MLR). On Day + 100, a strong anti-host response was observed in MLR in the absence of graftversus-host disease (GVHD), together with near complete regression of the patient's lymphoma. A mild chronic GVHD later developed and, eventually, by 680 days postBMT, the lymphoma had relapsed and MLR reflected a state of global immune unresponsiveness. These observations demonstrate evolving host-versus-graft and graftversus-host tolerance that correlates with fluctuating lymphoid chimerism and graft-versus-lymphoma (GVL) effects, in the absence of severe GVHD. Eventual lymphoma relapse temporally correlated with a generalised immunosuppressed state. [ABSTRACT FROM AUTHOR]
- Subjects :
- *LYMPHOCYTES
*MOSAICISM
*BONE marrow transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 13684736
- Volume :
- 7
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Cytokines Cellular & Molecular Therapy
- Publication Type :
- Academic Journal
- Accession number :
- 9334146
- Full Text :
- https://doi.org/10.1080/13684730412331302054