Quantification of peramivir in dog plasma by liquid chromatography/tandem mass spectrometry employing precolumn derivatization.

Highlights: [•] The LLOQ of this method is better than previous published methods. [•] The esterification derivatization was used to increase the HPLC retention time and ionization efficiency in this article. [•] Peramivir is a novel anti-influenza drug which was shown to be safe and have well activity. [Copyright &y& Elsevier]