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Pumped up: reflections on PfATP6 as the target for artemisinins.

Authors :
Krishna, Sanjeev
Pulcini, Serena
Moore, Catherine M.
Teo, Beatrix Huei-Yi
Staines, Henry M.
Source :
Trends in Pharmacological Sciences. Jan2014, Vol. 35 Issue 1, p4-11. 8p.
Publication Year :
2014

Abstract

Highlights: [•] Artemisinins are our most important class of antimalarial drugs. [•] PfATP6, a SERCA pump, is a proposed target for artemisinins in parasites. [•] Recent expression studies in yeast support this suggestion. [•] Other recent studies on PfATP6 are reviewed. [ABSTRACT FROM AUTHOR]

Subjects

Subjects :
*ARTEMISININ
*TARGETED drug delivery
*ADENOSINE triphosphatase
*ANTIMALARIALS
*GENE expression
*YEAST
*MICROORGANISMS

Details

Language :
English
ISSN :
01656147
Volume :
35
Issue :
1
Database :
Academic Search Index
Journal :
Trends in Pharmacological Sciences
Publication Type :
Academic Journal
Accession number :
93414490
Full Text :
https://doi.org/10.1016/j.tips.2013.10.007
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