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Highly Efficient CH Hydroxylation of Carbonyl Compounds with Oxygen under Mild Conditions.
- Source :
-
Angewandte Chemie International Edition . Jan2014, Vol. 53 Issue 2, p548-552. 5p. - Publication Year :
- 2014
-
Abstract
- A transition-metal-free Cs2CO3-catalyzed α-hydroxylation of carbonyl compounds with O2 as the oxygen source is described. This reaction provides an efficient approach to tertiary α-hydroxycarbonyl compounds, which are highly valued chemicals and widely used in the chemical and pharmaceutical industry. The simple conditions and the use of molecular oxygen as both the oxidant and the oxygen source make this protocol very environmentally friendly and practical. This transformation is highly efficient and highly selective for tertiary C(sp3)H bond cleavage. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 53
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 93427085
- Full Text :
- https://doi.org/10.1002/anie.201308698